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Health.cat news The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Case 12-2017 ? A 34-Year-Old Man with Nephropathy
01/01/70 - Presentation of Case. Dr. Daniel H. Katz (Medicine): A 34-year-old man with hearing impairment was admitted to this hospital because of worsening renal function. The patient had been well until approximately 11 weeks before this admission, when subjective fevers with sweats, fatigue, decreased…

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
01/01/70 - Monoclonal antibodies that inhibit proprotein convertase subtilisin?kexin type 9 (PCSK9) lower levels of plasma low-density lipoprotein (LDL) cholesterol and are promising agents for vascular risk reduction. Patients who have received the fully human monoclonal antibodies evolocumab and alirocumab,…

Sickle Cell Disease
01/01/70 - Sickle cell disease is an increasing global health problem. Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as homozygosity for the sickle hemoglobin (HbS) gene (i.e. for a missense mutation [Glu6Val, rs334] in the ?-globin gene…

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab
01/01/70 - Reducing levels of low-density lipoprotein (LDL) cholesterol with statin therapy is a highly effective method for reducing cardiovascular risk. Trial data, observational studies, and genetic analyses indicate that further reductions in LDL cholesterol levels are likely to confer greater…

Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes
01/01/70 - Diabetic retinopathy is the most common cause of blindness in adults in the United States. Fortunately, the risk of the development and progression of retinopathy can be reduced substantially by modern-day intensive glycemic management. Moreover, if clinically significant macular edema or…

Zika Virus Infection and Associated Neurologic Disorders in Brazil
01/01/70 - To the Editor: The first cases of a new illness involving fever and rash that was deemed to have been caused by Zika virus (ZIKV) infection in Brazil were reported in 2014, and the presence of the virus was confirmed in April 2015. In October 2015, an unusual increase in the number of cases of…

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia
01/01/70 - In patients with aplastic anemia, the "empty" bone marrow does not produce blood cells, and when pancytopenia is severe and untreated, almost all patients die within 1 year after diagnosis. Acquired aplastic anemia has immune pathophysiological features, as inferred from numerous laboratory studies…

Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis
01/01/70 - Psoriasis is a chronic immune-mediated inflammatory skin disease that occurs in 2% of adults; it has a substantial effect on quality of life and is associated with obesity, hypertension, diabetes mellitus, hypercholesterolemia, and the metabolic syndrome. The proinflammatory cytokine interleukin-23…

The Art of Repeal ? Republicans? Health Care Reform Muddle
01/01/70 - Failure is a familiar outcome in U.S. health policy. Presidents have long struggled to translate their promises and aspirations into legislative victory. Harry Truman?s national health insurance program never came close to becoming law. Richard Nixon?s universal coverage plan did not pass. Congress…

Reevaluating Eligibility Criteria ? Balancing Patient Protection and Participation in Oncology Trials
01/01/70 - Eligibility criteria for clinical trials are designed to protect patients from undue harm, define the study population, and permit collection of safety and efficacy data specific to the intended population. But too frequently, eligibility criteria are simply duplicated from protocol to protocol…

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