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Health.cat news The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism
01/01/70 - Venous thromboembolism is a common complication of cancer and its therapy. Treatment of cancer-associated venous thromboembolism is challenging, and the risks of recurrent thrombosis and bleeding are higher among patients with cancer than among those without cancer. These two complications are…

Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma
01/01/70 - The risk of multiple myeloma increases with age, and despite progress in the development of effective treatment, the disease remains incurable. The most widely approved regimens for elderly patients are lenalidomide plus dexamethasone and ? outside the United States ? melphalan, prednisone, and…

Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin?s Lymphoma
01/01/70 - Outcomes for patients with advanced-stage Hodgkin?s lymphoma have improved dramatically over the past half century. Although regional differences exist, the most commonly used frontline regimen ? doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) ? has not been modified since its original…

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
01/01/70 - Large B-cell lymphomas, including diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, and transformed follicular lymphoma, are treated with combination chemoimmunotherapy at diagnosis. Patients who have a relapse with chemotherapy-sensitive disease may be treated with high-dose…

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
01/01/70 - Diffuse large B-cell lymphoma, the most common non-Hodgkin?s lymphoma, is successfully treated in about two thirds of patients with rituximab-based immunochemotherapy. When current frontline immunochemotherapy fails, high-dose chemotherapy with autologous stem-cell transplantation can lead to…

A Milestone for CAR T Cells
01/01/70 - More than 7 years have passed since the regression of advanced lymphoma was first reported in a patient who had undergone the infusion of T cells engineered to express a chimeric antigen receptor (CAR) targeting the CD19 antigen expressed on the surface of both normal and malignant B cells.…

Progress in the Treatment of Hodgkin?s Lymphoma
01/01/70 - Although there has been considerable research activity in the treatment of Hodgkin?s lymphoma since advanced stages of the disease became curable with combination chemotherapy in the 1960s, the most significant advances have involved the maintenance of a particular level of antitumor efficacy while…

AAV5?Factor VIII Gene Transfer in Severe Hemophilia A
01/01/70 - Hemophilia A, an X-linked bleeding disorder, results from mutations in the gene encoding coagulation factor VIII. Patients with severe hemophilia A (factor VIII activity level, Although many patients with hemophilia A receive exogenous factor VIII only when bleeding occurs (on-demand therapy), the…

A Cure for Hemophilia within Reach
01/01/70 - Severe hemophilia has changed from a debilitating disease to a condition that is compatible with normal life, provided that patients receive a diagnosis early and also receive prophylactic therapy. The disease burden is now related largely to the demanding infusions and the development of…

Contemporary Hormonal Contraception and the Risk of Breast Cancer
01/01/70 - An estimated 140 million women worldwide use hormonal contraception; this number accounts for approximately 13% of women between the ages of 15 and 49 years. In Denmark, this percentage increased from 24% in 1995 to 39% in 2012. Estrogen promotes the development of breast cancer, the leading cancer…

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