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Health.cat news The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
01/01/70 - Type 2 diabetes mellitus is associated with a substantial risk of cardiovascular and renal disease. The use of inhibitors of sodium?glucose cotransporter 2 (SGLT2) results in favorable effects on biomarkers, including glycemia, blood pressure, weight, intrarenal hemodynamics, and albuminuria, and…

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
01/01/70 - Preeclampsia is an important cause of death and complications for the mother and baby. The risk of such complications is considerably higher when the disease is severe and of early onset, leading to preterm birth at less than 37 weeks of gestation. Major challenges in modern obstetrics are the…

Improved Survival with Bevacizumab in Advanced Cervical Cancer
01/01/70 - Improved Survival with Bevacizumab in Advanced Cervical Cancer Original Article, N Engl J Med 2014;370:734-743. In Figure 1 (page 737), the number of patients in the top box should have been 452, rather than 425. Also, in Figure 2B (page 739) the curves should have started at 100% on the y axis…

Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer
01/01/70 - Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer Original Article, N Engl J Med 2017;377:122-131. The authors' disclosure statement was omitted from the print edition: "Dr. von Minckwitz reports receiving grant support paid to his institution from Pfizer, Celgene, Novartis,…

Signs
01/01/70 - Not long after my mother died, my father lay disconsolate in a darkened hotel room begging his deceased wife to send him a sign. Wherever she was in her ghostly habitat, would she please smuggle him some affirmation of their enduring love? Suddenly, the overhead light switched on. Other people…

Cognitive Function in a Randomized Trial of Evolocumab
01/01/70 - Statin therapy, ezetimibe, and the proprotein convertase subtilisin?kexin type 9 (PCSK9) inhibitor evolocumab have been shown to reduce the rate of cardiovascular events among patients with established cardiovascular disease. These therapies may result in very low levels of low-density lipoprotein…

Aspirin to Prevent Preeclampsia
01/01/70 - Not long after the physiological effects of prostacyclin (epoprostenol) and thromboxane on platelets and vessel walls were elucidated, it was suggested that many of the pathophysiological features of preeclampsia might be explained by disordered eicosanoid metabolism. The effects of aspirin in low…

Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass
01/01/70 - In the 1990s, enthusiasm reemerged for performing coronary-artery bypass grafting (CABG) surgery on a beating heart without the use of cardiopulmonary bypass (off pump). Patients with poor cardiac function or complex coexisting conditions (e.g. lung disease or stroke) initially appeared to have…

Changing the Discussion about On-Pump versus Off-Pump CABG
01/01/70 - The performance of coronary-artery bypass grafting (CABG) without the use of the heart?lung machine (pump) was introduced to avoid the damaging effects of cardiopulmonary bypass. On-pump CABG with cardiopulmonary bypass is generally performed on an arrested heart, and off-pump CABG on a beating…

Inflammatory Bowel Disease and the NLRP3 Inflammasome
01/01/70 - The majority of the immune cells in the body are located in the intestine, where they are spatially separated from more than 10 trillion microorganisms by a layer of mucus and a layer of epithelial cells. Deterioration of this physical barrier ? the result of invading pathogens or an unrestrained…

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