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The New England Journal of Medicine: Search Results in Pediatrics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Efficacy of Larotrectinib in TRK Fusion?Positive Cancers in Adults and Children
01/01/70 - The neurotrophic receptor tyrosine kinase genes NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (TRK) proteins TRKA, TRKB, and TRKC, respectively. After embryogenesis, TRK expression is limited primarily to the nervous system, where these kinases help regulate pain, proprioception,…

Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth
01/01/70 - Despite evidence of the success of rotavirus vaccines, more than 90 million infants still lack access to a rotavirus vaccine. Barriers to global implementation of the vaccine include cost, suboptimal efficacy in low-income countries, and lingering safety concerns. An oral rotavirus vaccine…

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
01/01/70 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is characterized by atrophy and weakness of the skeletal muscles of the limbs and trunk and of the bulbar and respiratory muscles. It is caused by homozygous deletions or loss-of-function mutations in the gene…

When the CHIPs Are Down ? Health Coverage and Care at Risk for U.S. Children
01/01/70 - Despite bipartisan agreement on a 5-year plan in both the Senate and the House of Representatives, Congress failed to reauthorize the Children?s Health Insurance Program (CHIP) last fall, causing uncertainty and worry for families and state CHIP directors alike. Families in several states,…

Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak ? Preliminary Report
01/01/70 - Yellow fever is a mosquito-borne viral disease endemic to tropical and subtropical regions in Africa and the Americas. Infection with yellow fever virus can result in subclinical to severe illness, characterized by fever, jaundice, and hemorrhage. There were an estimated 51,000 to 380,000 severe…

Case 4-2018: A Newborn with Thrombocytopenia, Cataracts, and Hepatosplenomegaly
01/01/70 - Presentation of Case. Dr. Madeleine I. Matthiesen (Medicine and Pediatrics): A newborn boy was transferred to the neonatal intensive care unit (ICU) of this hospital because of thrombocytopenia and abnormal results on an eye examination for red reflex and on a hearing screening. The patient was…

Herpetic Whitlow
01/01/70 - A previously healthy 1-year-old girl was admitted to the hospital with a 4-day history of fever, along with erythema and swelling of the left third finger. Bacterial cellulitis was suspected, and intravenous cefazolin was initiated. However, over the next 36 hours, the fever persisted (with a…

History of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease
01/01/70 - Chronic kidney disease and end-stage renal disease (ESRD) are global health problems with increasing prevalence. Early identification of persons at increased risk may allow for early interventions that might reduce the incidence of progressive chronic kidney disease and its associated…

A Disturbing Legacy of Childhood Kidney Disease
01/01/70 - Despite an apparent resolution of various kidney diseases during childhood, undetectable and poorly understood residual damage may confer an increased risk of chronic kidney disease in adulthood. In this issue of the Journal, Calderon-Margalit et al. provide long-term, though retrospective, data…

Where There?s Wildfire, There?s Smoke
01/01/70 - With the undeniable march of climate change, the danger of catastrophic wildfires is increasing around the globe, with such fires occurring in Australia, Canada, Chile, Indonesia, Portugal, and Russia, as well as the United States, over the past decade. Large forest fires in the western United…

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