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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Monoclonal Antibodies for Emerging Infectious Diseases ? Borrowing from History
01/01/70 - Although antibodies play pivotal roles in the immune response to infection, they have seen limited use as therapeutic agents for infectious diseases. Yet there is a long history of plasma-derived treatments for several pathogens. Emil Adolf von Behring, for example, won the Nobel Prize in…

Autoimmune Polyendocrine Syndromes
01/01/70 - Autoimmune polyendocrine syndromes comprise a diverse group of clinical conditions characterized by functional impairment of multiple endocrine glands due to loss of immune tolerance. These syndromes also frequently include conditions such as alopecia, vitiligo, celiac disease, and autoimmune…

Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations
01/01/70 - Asthma is one of the most common chronic diseases, with an estimated 300 million people affected worldwide. Acute exacerbations of asthma are frightening for patients, cause considerable illness and death, and account for a large proportion of the overall costs related to asthma. Although plans for…

Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
01/01/70 - Asthma exacerbations are common events, particularly in school-age children. Exacerbations are costly and are associated with considerable complications. In addition, asthma exacerbations may lead to progressive loss of lung function and greater asthma severity over time. Although conventional…

Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations
01/01/70 - Inhaled glucocorticoids are pivotal to achieve asthma control and disease stability in both children and adults; despite their use, with or without other treatments, many patients with asthma have ongoing episodic disease exacerbations. Often, these are linked to provocative factors such as viral…

Ambient Temperature and Screening for Nasopharyngeal Cancer
01/01/70 - To the Editor: Nasopharyngeal carcinoma is closely associated with Epstein?Barr virus (EBV) infection. In a recent prospective study involving more than 20,000 participants, detection of cancer-derived EBV DNA in plasma was shown to be useful in screening for nasopharyngeal carcinoma. Participants…

Antibody-Mediated Encephalitis
01/01/70 - Antibody-mediated encephalitides constitute a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms and are associated with antibodies against neuronal cell-surface proteins, ion channels, or receptors (Table 1). Common clinical features include a change…

Multiple Sclerosis
01/01/70 - Multiple sclerosis is the most prevalent chronic inflammatory disease of the central nervous system (CNS), affecting more than 2 million people worldwide (at least 400,000 in the United States), and it is currently incurable. It is punctuated by fully or partially reversible episodes of neurologic…

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma
01/01/70 - Scleroderma with internal-organ involvement (diffuse cutaneous systemic sclerosis) is a devastating autoimmune disorder. Despite advances in management, mortality driven by pulmonary involvement has not changed in 40 years. Although disease-modifying antirheumatic drugs (DMARDs) and biologics have…

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease
01/01/70 - Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow obstruction, chronic inflammation in the lungs, and the occurrence of persistent symptoms and acute exacerbations. Up to 40% of patients with COPD have an eosinophilic phenotype, defined as a…

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