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The New England Journal of Medicine: Search Results in Pulmonary\Critical Care
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary\Critical Care. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Tezacaftor?Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis
01/01/70 - Cystic fibrosis is a progressive, systemic, life-limiting, autosomal recessive disease that is caused by reduced quantity or function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein due to mutations in the CFTR gene. Loss of chloride transport activity due to defects in…

Case 36-2017: A 30-Year-Old Man with Fatigue, Rash, Anemia, and Thrombocytopenia
01/01/70 - Presentation of Case. Dr. Amy E. Yuan (Medicine): A 30-year-old man was admitted to this hospital during the summer because of fatigue, rash, fevers, anemia, and thrombocytopenia. Three years before this admission, the patient was involved in a motor vehicle accident that resulted in a large…

Tezacaftor?Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del
01/01/70 - Cystic fibrosis is caused by a reduced quantity or function of cystic fibrosis transmembrane conductance regulator (CFTR) protein, owing to mutations in CFTR. A loss of chloride secretion causes impaction of mucus in the airways, gastrointestinal tract, and exocrine organs, with important clinical…

CFTR Modulator Therapy for Cystic Fibrosis
01/01/70 - Cystic fibrosis is a disease of abnormal ion transport through epithelium that results in progressive lung disease as well as the involvement of other organs including the pancreas, gut, and liver. Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane…

Osimertinib in Untreated EGFR-Mutated Advanced Non?Small-Cell Lung Cancer
01/01/70 - The current standard of care for patients with locally advanced or metastatic non?small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)?sensitizing mutations is treatment with a first-generation or second-generation EGFR-TKI such as…

Durvalumab after Chemoradiotherapy in Stage III Non?Small-Cell Lung Cancer
01/01/70 - Approximately one third of patients with non?small-cell lung cancer (NSCLC) have stage III, locally advanced disease at diagnosis. The standard of care for patients with a good performance status and unresectable stage III NSCLC is platinum-based doublet chemotherapy concurrent with radiotherapy…

Immunotherapy for Unresectable Stage III Non?Small-Cell Lung Cancer
01/01/70 - In this issue of the Journal, Antonia and colleagues report the results of the phase 3 PACIFIC study, which evaluated the role of immune checkpoint blockade in locally advanced, unresectable, stage III non?small-cell lung cancer (NSCLC). Eligible patients had disease that had not yet progressed…

The Code, the Cloud, and the Doppler
01/01/70 - Janna insisted that the oscillator made the perfect white noise machine. It was almost loud enough to drown out the heart-rate monitor. Even so, when Kynslee?s heart rate, blood pressure, or oxygen saturation went out of range, a louder alarm would blare and flashing red lights would bring the…

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults
01/01/70 - Red-cell transfusions are common in critically ill patients, and red cells may be stored for up to 42 days depending on manufacturing process, additive solution, and local policies or regulations. During storage, red cells undergo structural, biochemical, and metabolic changes, known as the…

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease
01/01/70 - Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow obstruction, chronic inflammation in the lungs, and the occurrence of persistent symptoms and acute exacerbations. Up to 40% of patients with COPD have an eosinophilic phenotype, defined as a…

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