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The New England Journal of Medicine: Search Results in Pulmonary\Critical Care
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary\Critical Care. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Oral Glucocorticoid?Sparing Effect of Benralizumab in Severe Asthma
01/01/70 - Asthma is a common chronic inflammatory disease of the airways that affects an estimated 315 million persons worldwide. Approximately 5 to 10% of persons with asthma have a severe form of disease that is usually managed with high-dose inhaled glucocorticoids and bronchodilators. Within this group,…

Angiotensin II for the Treatment of Vasodilatory Shock
01/01/70 - Shock is a life-threatening syndrome characterized by decreased organ perfusion that can progress to irreversible organ failure. Vasodilatory shock is the most common type of shock and is characterized by peripheral vasodilation and reduced blood pressure despite preserved cardiac output.…

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis
01/01/70 - More than 1.5 million cases of sepsis occur in the United States annually, and many patients with sepsis present to the emergency department. International clinical practice guidelines and the Centers for Medicare and Medicaid Services (CMS) recommend the prompt identification of sepsis and…

State Sepsis Mandates ? A New Era for Regulation of Hospital Quality
01/01/70 - Sepsis is a major cause of illness and death in the United States, affecting more than 1.5 million Americans each year at an annual cost of over $20 billion. To improve outcomes of sepsis, policymakers are increasingly using regulatory mechanisms intended to provide incentives to clinicians and…

Physiological Effects of Chronic Hypoxia
01/01/70 - The physiology of chronic hypoxia encompasses an enormous field of knowledge. This review concentrates on two areas in which important advances have recently been made. The first is hypoxia-inducible factors (HIFs), which constitute the master switch in the human response to hypoxia. The second is…

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
01/01/70 - Many patients with severe asthma do not have adequate disease control despite the use of high-dose inhaled or systemic glucocorticoids. Severe asthma is associated with airway hyperresponsiveness ? that is, an exaggerated response to a bronchoconstrictor stimulus ? and airway inflammation, both of…

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis
01/01/70 - Eosinophilic granulomatosis with polyangiitis (formerly known as the Churg?Strauss syndrome) is characterized by asthma, sinusitis, pulmonary infiltrates, neuropathy, and eosinophilic vasculitis of one or more end-organs. Eosinophils are thought to induce pathogenic effects in patients with…

Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma
01/01/70 - Mast cells and many of their secreted products have long been thought to contribute to the pathologic processes underlying asthma, but no clinical studies have assessed whether specifically targeting mast-cell survival or development would have therapeutic benefit in the treatment of this disorder.…

Tracking the Evolution of Non?Small-Cell Lung Cancer
01/01/70 - Lung cancer is the leading cause of cancer-related death worldwide, with non?small-cell lung cancer (NSCLC) being the most common type. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lung adenocarcinomas and lung squamous-cell…

Netting Insights into Fibrosis
01/01/70 - Fibrosis refers to the excessive deposition of extracellular matrix in a reparative or reactive process after tissue damage. Excessive fibrosis, which can occur during chronic inflammation and aging, contributes substantially to illness and death. It affects essential organs such as the heart,…

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