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The New England Journal of Medicine: Search Results in Pulmonary\Critical Care
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary\Critical Care. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Oral Glucocorticoid?Sparing Effect of Benralizumab in Severe Asthma
01/01/70 - Asthma is a common chronic inflammatory disease of the airways that affects an estimated 315 million persons worldwide. Approximately 5 to 10% of persons with asthma have a severe form of disease that is usually managed with high-dose inhaled glucocorticoids and bronchodilators. Within this group,…

First-Line Nivolumab in Stage IV or Recurrent Non?Small-Cell Lung Cancer
01/01/70 - For the past two decades, platinum-based combination chemotherapy has been the standard-of-care, first-line treatment for patients with advanced non?small-cell lung cancer (NSCLC) without mutations that were sensitive to targeted therapy. However, chemotherapy has provided only a moderate benefit,…

Cancer Immunotherapy Trials Not Immune from Imprecise Selection of Patients
01/01/70 - Arguably, no drug class has more radically and rapidly altered the management of non?small-cell lung cancer (NSCLC) than inhibitors of the interaction between programmed death 1 (PD-1) and its ligand PD-L1. By impeding this negative regulatory signal for T-cell response, PD-1 and PD-L1 inhibitors…

State Sepsis Mandates ? A New Era for Regulation of Hospital Quality
01/01/70 - Sepsis is a major cause of illness and death in the United States, affecting more than 1.5 million Americans each year at an annual cost of over $20 billion. To improve outcomes of sepsis, policymakers are increasingly using regulatory mechanisms intended to provide incentives to clinicians and…

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis
01/01/70 - More than 1.5 million cases of sepsis occur in the United States annually, and many patients with sepsis present to the emergency department. International clinical practice guidelines and the Centers for Medicare and Medicaid Services (CMS) recommend the prompt identification of sepsis and…

Early, Goal-Directed Therapy for Septic Shock ? A Patient-Level Meta-Analysis
01/01/70 - In 2001, Rivers and colleagues reported on a 263-patient, single-center, randomized, controlled trial of early, goal-directed therapy (EGDT) versus usual care in patients presenting with septic shock to an urban emergency department in the United States. EGDT is a 6-hour resuscitation protocol for…

Management of Septic Shock
01/01/70 - Ms. Jones has been admitted to the ICU with septic shock and is receiving vasopressors to elevate her mean arterial pressure. Shortly after her arrival, her condition deteriorates, and intubation and mechanical ventilation are initiated because of acute lung injury. The increased lactate level and…

Spiraling Out of Control
01/01/70 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors? commentary follows. Stage. A 22-year-old man presented to the…

Levosimendan for Hemodynamic Support after Cardiac Surgery
01/01/70 - Every year, more than 1 million patients undergo cardiac surgery in the United States and Europe. Acute perioperative left ventricular dysfunction is a major complication affecting up to 20% of such patients and is associated with increased mortality. Inotropic drugs (catecholamines and…

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery
01/01/70 - Cardiac surgery with the use of cardiopulmonary bypass is a common procedure, with more than 1 million operations performed annually in the United States and Europe. Increasingly, patients who are referred for cardiac surgery are older and have multiple coexisting conditions, as compared with those…

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