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The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Sickle Cell Disease
01/01/70 - Sickle cell disease is an increasing global health problem. Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as homozygosity for the sickle hemoglobin (HbS) gene (i.e. for a missense mutation [Glu6Val, rs334] in the ?-globin gene…

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia
01/01/70 - In patients with aplastic anemia, the "empty" bone marrow does not produce blood cells, and when pancytopenia is severe and untreated, almost all patients die within 1 year after diagnosis. Acquired aplastic anemia has immune pathophysiological features, as inferred from numerous laboratory studies…

Reevaluating Eligibility Criteria ? Balancing Patient Protection and Participation in Oncology Trials
01/01/70 - Eligibility criteria for clinical trials are designed to protect patients from undue harm, define the study population, and permit collection of safety and efficacy data specific to the intended population. But too frequently, eligibility criteria are simply duplicated from protocol to protocol…

Case 11-2017 ? A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis
01/01/70 - Presentation of Case. Dr. Areej El-Jawahri (Hematology?Oncology): A 61-year-old woman was seen in the emergency department of this hospital because of leg swelling and back pain. The patient had been in her usual health until approximately 3 months before this presentation, when mild swelling of…

Who Decides When a Patient Can?t? Statutes on Alternate Decision Makers
01/01/70 - Many patients cannot make their own medical decisions, having lost what is called decisional capacity. The estimated prevalence of decisional incapacity approaches 40% among adult medical inpatients and residential hospice patients and exceeds 90% among adults in some intensive care units. Patients…

Ensuring Access to Injectable Generic Drugs ? The Case of Intravesical BCG for Bladder Cancer
01/01/70 - In November 2016, one of the two manufacturers of bacille Calmette?Guérin (BCG) informed health care providers that it planned to exit the market in mid-2017. Intravesical immunotherapy with BCG is the standard of treatment for preventing recurrence and disease progression in high-risk patients…

Changes in France?s Deferral of Blood Donation by Men Who Have Sex with Men
01/01/70 - To the Editor: Since the advent of AIDS, men who have sex with men (MSM) have often been permanently deferred from blood donation in France and elsewhere. Such a ban, which is more stringent than deferrals for other risk exposures, can be considered to be discriminatory and often is misunderstood.…

Acute Spinal Cord Compression
01/01/70 - Acute compression of the spinal cord is a devastating but treatable disorder. Diseases that cause acute spinal cord compression constitute a special category because they originate in the spinal column and narrow the spinal canal. This review addresses the disorders that account for most instances…

Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma
01/01/70 - For the past 20 years, high-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age. However, this treatment requires hospitalization and can be associated with substantial toxic effects. Over…

Transplantation for Myeloma ? Now or Later?
01/01/70 - The outlook for patients with multiple myeloma has improved dramatically during the past two decades. The median overall survival is now more than 6 years, as compared with an overall survival of 3 to 4 years during the era of treatment with alkylating agents and anthracyclines. This progress…

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