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Nejm News Une Mise à Jour The New England Journal of Medicine by Specialties

 


The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Case 36-2017: A 30-Year-Old Man with Fatigue, Rash, Anemia, and Thrombocytopenia
01/01/70 - Presentation of Case. Dr. Amy E. Yuan (Medicine): A 30-year-old man was admitted to this hospital during the summer because of fatigue, rash, fevers, anemia, and thrombocytopenia. Three years before this admission, the patient was involved in a motor vehicle accident that resulted in a large…

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis
01/01/70 - Fatty liver disease is the most common liver disease in the world. About 25% of adults in the United States have fatty livers in the absence of excessive alcohol consumption, a condition termed nonalcoholic fatty liver disease. More than a quarter of adults with nonalcoholic fatty liver disease are…

Osimertinib in Untreated EGFR-Mutated Advanced Non?Small-Cell Lung Cancer
01/01/70 - The current standard of care for patients with locally advanced or metastatic non?small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)?sensitizing mutations is treatment with a first-generation or second-generation EGFR-TKI such as…

Durvalumab after Chemoradiotherapy in Stage III Non?Small-Cell Lung Cancer
01/01/70 - Approximately one third of patients with non?small-cell lung cancer (NSCLC) have stage III, locally advanced disease at diagnosis. The standard of care for patients with a good performance status and unresectable stage III NSCLC is platinum-based doublet chemotherapy concurrent with radiotherapy…

Lomustine and Bevacizumab in Progressive Glioblastoma
01/01/70 - No standard of care has been established for patients with progressive glioblastoma. Previous studies suggested that bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor, is safe and produces responses that result in a decreased use of glucocorticoids and increased…

Immunotherapy for Unresectable Stage III Non?Small-Cell Lung Cancer
01/01/70 - In this issue of the Journal, Antonia and colleagues report the results of the phase 3 PACIFIC study, which evaluated the role of immune checkpoint blockade in locally advanced, unresectable, stage III non?small-cell lung cancer (NSCLC). Eligible patients had disease that had not yet progressed…

Methemoglobinemia Due to Antifreeze Ingestion
01/01/70 - To the Editor: Ingestion of antifreeze that contains ethylene glycol produces acidosis, nephropathy, coma, and cardiovascular collapse. Previously, minimal increases in methemoglobin levels (to as high as 6%; normal value, Our patient, a 62-year-old man with a history of depression, presented to an…

Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
01/01/70 - The avoidance of unnecessary blood transfusion is a high priority; therefore, determining safe thresholds for transfusion is imperative. Among the highest recipients of red-cell transfusion are patients undergoing cardiac surgery, with a substantial proportion of the total blood supply used by this…

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
01/01/70 - In estrogen-receptor (ER)?positive early-stage breast cancer, 5 years of adjuvant endocrine therapy substantially reduces the risks of locoregional and distant recurrence, contralateral breast cancer, death from breast cancer, and hence death from any cause. In trials of 5 years of tamoxifen…

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults
01/01/70 - Red-cell transfusions are common in critically ill patients, and red cells may be stored for up to 42 days depending on manufacturing process, additive solution, and local policies or regulations. During storage, red cells undergo structural, biochemical, and metabolic changes, known as the…

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