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The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation
01/01/70 - Approximately 5% of unselected patients with breast cancer carry a germline BRCA mutation. Such mutations are more likely to be present in patients who have a strong family history of breast cancer, younger patients, patients who have triple-negative (i.e. human epidermal growth factor receptor…

Case 24-2017: An 8-Month-Old Girl with Fever and an Abdominal Mass
01/01/70 - Presentation of Case. Dr. Rajitha Venkatesh (Pediatrics): An 8-month-old girl was admitted to this hospital because of fever and an abdominal mass. The patient had been in her usual good health until approximately 6 days before admission, when she passed a large stool surrounded by clotted blood.…

Analysis of Plasma Epstein?Barr Virus DNA to Screen for Nasopharyngeal Cancer
01/01/70 - Analysis of circulating DNA derived from cancer cells, which is frequently known as a "liquid biopsy," is being evaluated as a tool in the care of patients with cancer. Although a wide range of cancer-associated changes, including point mutations, copy-number aberrations, and alterations in DNA…

Plasma Epstein?Barr Virus DNA for Screening
01/01/70 - In this issue of the Journal, Chan et al. report on the monitoring of Epstein?Barr virus (EBV) DNA in plasma samples to screen a population that was at high risk for nasopharyngeal carcinoma. Although interest in monitoring circulating cell-free tumor DNA has surged, the application of this method…

Idarucizumab for Dabigatran Reversal ? Full Cohort Analysis
01/01/70 - Patients who are receiving oral anticoagulant therapy for the prevention or treatment of thrombosis may benefit from anticoagulant reversal if they present with life-threatening bleeding or if they will be undergoing urgent surgery or intervention. Therefore, the availability of specific reversal…

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
01/01/70 - Acute myeloid leukemia (AML) is a heterogeneous disease that remains challenging to treat because of patient factors (age and coexisting diseases) and intrinsic biologic factors. Cytogenetic and mutational data are used to divide patients into subgroups defined according to prognostic factors and…

End-of-Life Decisions in the Netherlands over 25 Years
01/01/70 - To the Editor: In the Netherlands, the much debated practice of physician assistance in dying has been legally regulated since 2002. Such assistance may include physician-assisted suicide or euthanasia, in which a physician administers lethal medication at the explicit request of a patient. Both…

Potential Pitfall of Pluripotent Stem Cells
01/01/70 - Pluripotent stem cells are entering early phase 1 and 2 clinical trials for a range of applications, including the treatment of macular degeneration and other eye diseases, spinal cord injury, heart disease, type 1 diabetes, and Parkinson?s disease. By necessity, both pluripotent embryonic stem…

Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
01/01/70 - Metastatic, castration-sensitive prostate cancer accounts for approximately 3% of all new prostate-cancer diagnoses in the United States. Historically, androgen-deprivation therapy consisting of bilateral orchiectomy or luteinizing hormone?releasing hormone analogues, with or without…

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
01/01/70 - The Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial recruits patients commencing long-term androgen-deprivation therapy (ADT; orchiectomy or gonadotropin-releasing hormone [GnRH] agonists or antagonists) for the first time for locally…

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