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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
01/01/70 - Type 2 diabetes mellitus is associated with a substantial risk of cardiovascular and renal disease. The use of inhibitors of sodium?glucose cotransporter 2 (SGLT2) results in favorable effects on biomarkers, including glycemia, blood pressure, weight, intrarenal hemodynamics, and albuminuria, and…

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
01/01/70 - Preeclampsia is an important cause of death and complications for the mother and baby. The risk of such complications is considerably higher when the disease is severe and of early onset, leading to preterm birth at less than 37 weeks of gestation. Major challenges in modern obstetrics are the…

Nitroprusside and Isoproterenol Use after Major Price Increases
01/01/70 - To the Editor: A number of important pharmaceuticals have undergone dramatic price increases recently. For example, nitroprusside prices have increased by a factor of 30 (wholesale acquisition cost [WAC, the manufacturer?s published catalogue or list price to wholesalers, which may not represent…

Angiotensin II for the Treatment of Vasodilatory Shock
01/01/70 - Shock is a life-threatening syndrome characterized by decreased organ perfusion that can progress to irreversible organ failure. Vasodilatory shock is the most common type of shock and is characterized by peripheral vasodilation and reduced blood pressure despite preserved cardiac output.…

Angiotensin II for the Treatment of Vasodilatory Shock ? Promise and Caution
01/01/70 - Shock is one of the most common reasons for admission of patients to an intensive care unit. Low blood pressure is a hallmark of shock, and raising blood pressure is one of the foremost therapeutic goals in this setting. In patients with vasodilatory (i.e. "distributive") shock, who represent…

Xanthomas in Familial Hypercholesterolemia
01/01/70 - Figure 1.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
01/01/70 - Angiopoietin-like proteins (ANGPTLs) have been established as important regulators of lipoprotein metabolism and have thus emerged as attractive targets for modulation of lipid levels and cardiovascular disease risk. Loss-of-function variants in ANGPTL4, a negative regulator of lipoprotein lipase…

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
01/01/70 - Despite advances in the development of lipid-lowering therapies, clinical trials have shown that a substantial risk of cardiovascular disease persists after currently recommended medical therapy. For example, in one trial involving patients who had had an acute coronary syndrome, the lowering of…

Increasing Lipolysis and Reducing Atherosclerosis
01/01/70 - In patients with coronary artery disease, residual cardiovascular risk remains substantial even after levels of low-density lipoprotein (LDL) cholesterol have been effectively lowered by treatment with statins, ezetimibe, or antibodies targeting proprotein convertase subtilisin?kexin type 9…

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia
01/01/70 - To the Editor: Homozygous familial hypercholesterolemia is characterized by profound genetic deficiencies in the low-density lipoprotein (LDL) receptor pathway; patients with the condition who are not receiving lipid-lowering therapy have LDL cholesterol levels in the range of 500 to 1000 mg per…

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