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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Mechanisms, Pathophysiology, and Management of Obesity
01/01/70 - Seven of the top 10 leading causes of death and disability in the United States today are chronic diseases (e.g. cancer and diabetes). Prevention and treatment of most of these conditions must address the close link with obesity. People who are overweight or obese account for more than two thirds…

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery
01/01/70 - Excessive bleeding and blood transfusions are common in patients undergoing cardiac surgery, and in some of these patients, there is a need for reoperation because of life-threatening bleeding. Both blood transfusion and reoperation are strongly associated with poor outcomes after cardiac surgery.…

Fibromuscular Dysplasia of the Brachial Artery
01/01/70 - Figure 1.

Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
01/01/70 - Peripheral artery disease is considered to be a clinical manifestation of systemic atherosclerosis affecting the vascular territories supplying the lower limbs. Most patients presenting with peripheral artery disease do not have a clinical history of cardiac or cerebral ischemic events, yet these…

Arrhythmogenic Right Ventricular Cardiomyopathy
01/01/70 - Arrhythmogenic right ventricular cardiomyopathy (ARVC), also known as arrhythmogenic right ventricular dysplasia, is a heritable heart-muscle disorder that predominantly affects the right ventricle. Progressive loss of right ventricular myocardium and its replacement by fibrofatty tissue is the…

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
01/01/70 - An elevated level of low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Despite the use of statin therapy, alone or in combination with other lipid-lowering medications, many at-risk patients continue to have elevated levels of LDL cholesterol. Hence, there…

Oligonucleotide Therapeutics ? A New Class of Cholesterol-Lowering Drugs
01/01/70 - Not long ago, the cholesterol-lowering arena was monopolized by small-molecule drugs, most of them statins. The recent approval by the Food and Drug Administration (FDA) of alirocumab (Praluent, Sanofi/Regeneron) and evolocumab (Repatha, Amgen), monoclonal antibodies targeting proprotein convertase…

Targeting Therapeutic Oligonucleotides
01/01/70 - Oligonucleotides are increasingly recognized as potential therapeutic agents for a variety of diseases. This is particularly true for the treatment of genetic diseases and cancer, for which an increasing number of molecular targets are being identified. Moreover, oligonucleotides can ? at least in…

Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis
01/01/70 - Nonsteroidal antiinflammatory drugs (NSAIDs) were introduced in the 1960s and became the most widely prescribed class of drugs in the world, with more than 100 million prescriptions issued annually in the United States alone. NSAIDs inhibit cyclooxygenase (COX), which reduces pain and inflammation…

Randomized Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts
01/01/70 - Coronary-artery bypass grafting (CABG) is one of the most commonly performed operations worldwide and has been established as an effective treatment for symptomatic multivessel coronary artery disease. The standard surgical approach is anastomosis of the left internal thoracic (mammary) artery to…

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