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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
01/01/70 - Monoclonal antibodies that inhibit proprotein convertase subtilisin?kexin type 9 (PCSK9) lower levels of plasma low-density lipoprotein (LDL) cholesterol and are promising agents for vascular risk reduction. Patients who have received the fully human monoclonal antibodies evolocumab and alirocumab,…

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab
01/01/70 - Reducing levels of low-density lipoprotein (LDL) cholesterol with statin therapy is a highly effective method for reducing cardiovascular risk. Trial data, observational studies, and genetic analyses indicate that further reductions in LDL cholesterol levels are likely to confer greater…

Antidrug Antibodies in Patients Treated with Alirocumab
01/01/70 - To the Editor: Immunogenicity led to the discontinuation of clinical development of bococizumab, a murine-derived, humanized antibody to proprotein convertase subtilisin?kexin type 9 (PCSK9), as now described by Ridker et al. in the Journal. Evidence suggests increased immunogenicity potential for…

Diagnosis and Differential Diagnosis of Cushing?s Syndrome
01/01/70 - More than a century ago, Harvey Cushing introduced the term "pluriglandular syndrome" to describe a disorder characterized by rapid development of central obesity, arterial hypertension, proximal muscle weakness, diabetes mellitus, oligomenorrhea, hirsutism, thin skin, and ecchymoses. Cushing knew…

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes
01/01/70 - Diabetes mellitus is a complex and heterogeneous group of chronic metabolic diseases that are characterized by hyperglycemia. Type 1 diabetes occurs predominantly in young people (diagnosis at 30 years of age or younger) and is generally thought to be precipitated by an immune-associated…

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
01/01/70 - Low-density lipoprotein (LDL) cholesterol is a causal factor in atherosclerotic cardiovascular disease. Statins have been shown to reduce LDL cholesterol levels and cardiovascular events in large outcome trials, findings that have made them the therapeutic cornerstone of clinical practice. Despite…

Delays in Emergency Care and Mortality during Major U.S. Marathons
01/01/70 - Preparation for large public events frequently involves road closures, an increase in emergency medical services, and interventions to ensure participant safety. In some instances, such as marathons, these changes may have unintended health consequences for nonparticipants. For example, widespread…

Netting Insights into Fibrosis
01/01/70 - Fibrosis refers to the excessive deposition of extracellular matrix in a reparative or reactive process after tissue damage. Excessive fibrosis, which can occur during chronic inflammation and aging, contributes substantially to illness and death. It affects essential organs such as the heart,…

Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure
01/01/70 - Acute presentation with new-onset heart failure and rapid worsening of preexisting heart failure are two of the most common causes of hospitalization worldwide. The disorder in each case is characterized by intravascular volume expansion and ventricular distention, which may cause myocardial injury…

Disease Modification in Acute Decompensated Heart Failure
01/01/70 - For patients with heart failure, hospitalization is associated with a downward clinical trajectory that accelerates with each subsequent admission. The risk of adverse events after hospitalization may be increased for patients who do not have reductions in levels of brain natriuretic peptide (BNP)…

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