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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Efficacy of Larotrectinib in TRK Fusion?Positive Cancers in Adults and Children
01/01/70 - The neurotrophic receptor tyrosine kinase genes NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (TRK) proteins TRKA, TRKB, and TRKC, respectively. After embryogenesis, TRK expression is limited primarily to the nervous system, where these kinases help regulate pain, proprioception,…

Developing Anticancer Drugs in Orphan Molecular Entities ? A Paradigm under Construction
01/01/70 - Genomic characterization of cancers has shown that some oncogenic alterations occur at very low frequency and are shared across tumor types. For example, NTRK translocations mediate malignant transformation and are observed in less than 1% of cancers and in more than 20 cancer types. The genes…

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
01/01/70 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is characterized by atrophy and weakness of the skeletal muscles of the limbs and trunk and of the bulbar and respiratory muscles. It is caused by homozygous deletions or loss-of-function mutations in the gene…

Innervating Prostate Cancer
01/01/70 - Thirty years ago, Sir James W. Black shared the Nobel Prize in Physiology or Medicine for his contribution to the development of propranolol (a beta-blocker) and cimetidine (a histamine H2 blocker). Since that time, beta-blockers have been and remain widely used as antihypertensive drugs. An…

Rejuvenating Regenerative Medicine Regulation
01/01/70 - The Food and Drug Administration (FDA) recently made long-awaited progress toward protecting patients from interventions involving human cell- and tissue-based products (HCT/P) of unknown safety and efficacy. By clarifying its position on the handling and therapeutic use of cells, the agency has…

Allogeneic Stem-Cell Transplantation ? A T-Cell Balancing ACT
01/01/70 - Success in the bone marrow transplantation clinic has always depended on scientific discovery. Before the discovery of histocompatibility antigens, for example, allogeneic hematopoietic stem-cell transplantation (HSCT) was uniformly fatal as a result of overwhelming immunologic catastrophe and…

Case 3-2018: A 5-Month-Old Boy with Hypoglycemia
01/01/70 - Presentation of Case. Dr. Micaela R. Atkins (Pediatrics): A 5-month-old boy was admitted to the pediatric intensive care unit (ICU) of this hospital for evaluation of suspected hypoglycemia. The patient was born at another hospital after 40 weeks 4 days of gestation. His mother had had a positive…

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
01/01/70 - Arteriovenous malformations of the brain are high-flow vascular malformations that occur in approximately 15 per 100,000 persons and cause hemorrhagic stroke in children. They are tortuous, morphologically abnormal vascular channels between arteries and veins that lack an intervening capillary…

Countering HIV ? Three?s the Charm?
01/01/70 - Antibodies have grown in importance as medicines over the more than 40 years since Köhler and Milstein first produced monoclonal constructs. However, the ability of human immunodeficiency virus (HIV) type 1 (HIV-1) to evade the humoral immune response has until recently thwarted the effective use…

Transfer of Fresh versus Frozen Embryos in Ovulatory Women
01/01/70 - In vitro fertilization (IVF) has evolved rapidly since its inception 40 years ago. Advancements include controlled ovarian stimulation with gonadotropin, which multiplied the number of oocytes retrieved, and embryo cryopreservation, which made it possible to conserve surplus embryos for further…

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