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Nejm News Une Mise à Jour The New England Journal of Medicine by Specialties

 


The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1
01/01/70 - LAD1 is a primary immunodeficiency resulting from mutations in ITGB2, which encodes the common CD18 subunit of the ?2 integrins; the ?2 integrins are required for the adhesion of neutrophils to endothelium and the transmigration of neutrophils into tissues. Patients with LAD1 typically have…

Breaking a Vicious Cycle
01/01/70 - In this issue of the Journal, Moutsopoulos et al. report on a patient with leukocyte adhesion deficiency type 1 (LAD1) who was successfully treated with ustekinumab, a monoclonal antibody to the p40 subunit common to interleukin-12 and interleukin-23. Patients with LAD1 have defective neutrophil…

Clarifying Stem-Cell Therapy?s Benefits and Risks
01/01/70 - The current excitement over the potential for stem-cell therapy to improve patient outcomes or even cure diseases is understandable. We at the Food and Drug Administration (FDA) share this excitement. However, to ensure that this emerging field fulfills its promise to patients, we must first…

Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD
01/01/70 - Age-related macular degeneration (AMD) is the leading cause of vision loss in persons older than 75 years of age in the United States. Progressive dysfunction and loss of retinal pigment epithelium cells and photoreceptors lead to poor visual acuity in patients with non-neovascular AMD. The…

Autologous Induced Stem-Cell?Derived Retinal Cells for Macular Degeneration
01/01/70 - Age-related macular degeneration (AMD) is one of the most prevalent retinal diseases that threaten vision in older populations in developed countries. Neovascular (also called "wet") AMD is more prevalent than atrophic (or "dry") AMD in Japan and is associated with the ectopic development of a…

Polar Extremes in the Clinical Use of Stem Cells
01/01/70 - The U.S. biotechnology and pharmaceutical industries arguably lead the world in innovation while operating under stringent regulations set by the Food and Drug Administration (FDA). Although flexible pathways exist to accelerate the development or approval of treatments for serious illnesses or…

Understanding Aging
01/01/70 - In 2006, Takahashi and Yamanaka reported the astonishing effect of forcing the simultaneous expression of a "cocktail" of four transcription factors (OCT4, SOX2, KLF4, and cMYC) on cells in the laboratory. This cocktail hijacked the controls and regulators that determine what a cell can or cannot…

Case 7-2017: A 73-Year-Old Man with Confusion and Recurrent Epistaxis
01/01/70 - Presentation of Case. Dr. Jeffrey L. Greenwald: A 73-year-old man with multiple chronic medical illnesses was admitted to this hospital because of confusion and irritability. Two days before this admission, increasing weakness, lethargy, chills, and diarrhea developed. The patient became less…

Gene Therapy in a Patient with Sickle Cell Disease
01/01/70 - Sickle cell disease is among the most prevalent inherited monogenic disorders. Approximately 90,000 people in the United States have sickle cell disease, and worldwide more than 275,000 infants are born with the disease annually. Sickle cell disease was the first disease for which the molecular…

Parsing the Pancreas
01/01/70 - The identity of any given cell is determined by its transcriptome ? that is, the set of genes that are actively transcribed into RNA in that cell. A disease condition or the elements of the cell environment, such as hormones, paracrine factors, and nutrients, can also determine the functional state…

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