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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Sickle Cell Disease
01/01/70 - Sickle cell disease is an increasing global health problem. Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as homozygosity for the sickle hemoglobin (HbS) gene (i.e. for a missense mutation [Glu6Val, rs334] in the ?-globin gene…

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Netting Insights into Fibrosis
01/01/70 - Fibrosis refers to the excessive deposition of extracellular matrix in a reparative or reactive process after tissue damage. Excessive fibrosis, which can occur during chronic inflammation and aging, contributes substantially to illness and death. It affects essential organs such as the heart,…

Primary Hyperoxaluria
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Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa
01/01/70 - To the Editor: Japanese encephalitis virus and yellow fever virus are mosquito-borne flaviviruses that circulate in disjunct geographic areas with different mosquito vectors. Japanese encephalitis is endemic to most of Asia and the Western Pacific, whereas yellow fever occurs in tropical areas of…

Dyskeratosis Congenita
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Repurposing a Bacterial Immune System to Discover Antiviral Targets
01/01/70 - The effect of new, easy-to-use tools for editing cellular genomes in medicine and biomedical science is difficult to overstate. The new method uses programmable DNA-cutting machinery from a bacterial immune system (CRISPR [clustered regularly interspaced short palindromic repeats]?Cas9), which can…

Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1
01/01/70 - LAD1 is a primary immunodeficiency resulting from mutations in ITGB2, which encodes the common CD18 subunit of the ?2 integrins; the ?2 integrins are required for the adhesion of neutrophils to endothelium and the transmigration of neutrophils into tissues. Patients with LAD1 typically have…

Breaking a Vicious Cycle
01/01/70 - In this issue of the Journal, Moutsopoulos et al. report on a patient with leukocyte adhesion deficiency type 1 (LAD1) who was successfully treated with ustekinumab, a monoclonal antibody to the p40 subunit common to interleukin-12 and interleukin-23. Patients with LAD1 have defective neutrophil…

Clarifying Stem-Cell Therapy?s Benefits and Risks
01/01/70 - The current excitement over the potential for stem-cell therapy to improve patient outcomes or even cure diseases is understandable. We at the Food and Drug Administration (FDA) share this excitement. However, to ensure that this emerging field fulfills its promise to patients, we must first…

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