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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
01/01/70 - Arteriovenous malformations of the brain are high-flow vascular malformations that occur in approximately 15 per 100,000 persons and cause hemorrhagic stroke in children. They are tortuous, morphologically abnormal vascular channels between arteries and veins that lack an intervening capillary…

Countering HIV ? Three?s the Charm?
01/01/70 - Antibodies have grown in importance as medicines over the more than 40 years since Köhler and Milstein first produced monoclonal constructs. However, the ability of human immunodeficiency virus (HIV) type 1 (HIV-1) to evade the humoral immune response has until recently thwarted the effective use…

IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries
01/01/70 - Since its successful introduction in 1978, in vitro fertilization (IVF) has traditionally been performed by the transfer of fresh embryos. In the first decades of IVF, the use of ovarian hyperstimulation allowed for the development and transfer of multiple embryos. As IVF technology improved, the…

Transfer of Fresh versus Frozen Embryos in Ovulatory Women
01/01/70 - In vitro fertilization (IVF) has evolved rapidly since its inception 40 years ago. Advancements include controlled ovarian stimulation with gonadotropin, which multiplied the number of oocytes retrieved, and embryo cryopreservation, which made it possible to conserve surplus embryos for further…

Rejuvenating Regenerative Medicine Regulation
01/01/70 - The Food and Drug Administration (FDA) recently made long-awaited progress toward protecting patients from interventions involving human cell- and tissue-based products (HCT/P) of unknown safety and efficacy. By clarifying its position on the handling and therapeutic use of cells, the agency has…

Favism and Glucose-6-Phosphate Dehydrogenase Deficiency
01/01/70 - Pythagoras of Samos, a great mathematician rather than a physician, may have been first in stating emphatically, in the 5th century b.c. that fava beans could be dangerous and even lethal for humans. This gives him a place in nutrition science but not in nutrogenomics: it seems he did not realize…

Toward a Culture of Scientific Inquiry ? The Role of Medical Teaching Services
01/01/70 - A major goal of academic medicine is to link patient care to scientific inquiry. The value of this linkage for understanding human biology has been recognized for over a century. Postmortem examinations of patients with aphasia drove the localization of higher brain functions, and studies of…

Making a Better Hematopoietic Stem Cell ? Timing Is Everything
01/01/70 - Allogeneic hematopoietic stem-cell (HSC) transplantation (HSCT) is a potentially lifesaving approach that is used to treat diseases ranging from congenital disorders, such as Fanconi?s anemia, to cancer. The key to any transplantation is successful donor-cell engraftment and function in the…

Poland Syndrome
01/01/70 - Figure 1.

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
01/01/70 - Diffuse large B-cell lymphoma, the most common non-Hodgkin?s lymphoma, is successfully treated in about two thirds of patients with rituximab-based immunochemotherapy. When current frontline immunochemotherapy fails, high-dose chemotherapy with autologous stem-cell transplantation can lead to…

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