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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
01/01/70 - Acute myeloid leukemia (AML) is a heterogeneous disease that remains challenging to treat because of patient factors (age and coexisting diseases) and intrinsic biologic factors. Cytogenetic and mutational data are used to divide patients into subgroups defined according to prognostic factors and…

Timing of Metastasis in Breast Cancer
01/01/70 - In 2015, almost 232,000 women in the United States received a diagnosis of invasive breast cancer, and approximately 40,000 women died of metastatic breast cancer. The leading cause of these deaths was metastatic spread. The timing and distribution of breast-cancer metastases vary considerably. In…

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
01/01/70 - Aging is associated with an increased incidence of cancer and cardiovascular disease. We and others recently used whole-exome sequencing data to identify a common, age-related disorder marked by an expansion of hematopoietic clones carrying recurrent somatic mutations, most frequently…

CHIP-ping Away at Atherosclerosis
01/01/70 - Efforts at prevention of cardiovascular disease hinge on the concept of risk factors that, when treated, attenuate the incidence of the disease. Since the concept of cardiovascular risk factors was first proposed in the Framingham Heart Study, many distinct risk algorithms have been developed to…

Case 17-2017: A 14-Year-Old Boy with Acute Fear of Choking while Swallowing
01/01/70 - Presentation of Case. Dr. Juliana Mariani (Pediatrics): A 14-year-old boy was seen in the emergency department of this hospital because of fear of choking while swallowing. The patient had been well until 2 days before admission, when he choked while eating a piece of chicken during dinner. He…

Reviving a Drug for Tuberculosis?
01/01/70 - The early days of tuberculosis drug development produced several drugs that now are used only rarely. Many are poorly effective or associated with common or serious toxic effects. For example, because of toxic effects seen at effective concentrations, ethionamide has been relegated to use in…

Myeloproliferative Neoplasms
01/01/70 - The myeloproliferative neoplasms ? polycythemia vera, essential thrombocytosis, and primary myelofibrosis ? are unique hematopoietic stem-cell disorders that share mutations that constitutively activate the physiologic signal-transduction pathways responsible for hematopoiesis (Table 1).…

Tracking the Evolution of Non?Small-Cell Lung Cancer
01/01/70 - Lung cancer is the leading cause of cancer-related death worldwide, with non?small-cell lung cancer (NSCLC) being the most common type. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lung adenocarcinomas and lung squamous-cell…

Seeing the Forest through the Phylogenetic Tree
01/01/70 - Cancer is generally considered to be a genetic disease. Tumors arise as a result of cumulative genetic alterations (gene mutations, copy-number changes, gene fusions, or RNA overexpression or underexpression) that affect the properties of single cells and endow them with a growth advantage. Early…

Sharing Clinical and Genomic Data on Cancer ? The Need for Global Solutions
01/01/70 - The Cancer Moonshot initiative has emphasized the importance of breaking down data silos to create a comprehensive and effective "cancer knowledge network" that would accelerate the combining of genomic, epidemiologic, and clinical information to improve patient outcomes. The real value of genomic…

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