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The New England Journal of Medicine: Search Results in Neurology\Neurosurgery
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology\Neurosurgery. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Orbital Apex Syndrome
01/01/70 - A 61-year-old man presented to the emergency department with a 3-week history of right retro-orbital pain and a 1-week history of double vision, lid droop, and loss of vision. Ophthalmologic examination revealed reduced vision in the right eye (only hand motion was perceived), a relative afferent…

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke
01/01/70 - Intravenous thrombolysis with alteplase is used in eligible patients with acute ischemic stroke before endovascular thrombectomy. Alteplase is given as an infusion over a period of approximately 1 hour and has been associated with a low incidence of reperfusion for large-vessel occlusion before…

Parental Mosaicism in "De Novo" Epileptic Encephalopathies
01/01/70 - To the Editor: De novo disease-causing variants have been increasingly recognized in apparently sporadic, severe neurologic disorders in children, including developmental and epileptic encephalopathies and autism. Geneticists indicate that the risk of recurrence of these disorders in families with…

Paving the Way for Improved Treatment of Acute Stroke with Tenecteplase
01/01/70 - The treatment of acute ischemic stroke is changing rapidly. Three years ago, endovascular thrombectomy was added to thrombolysis with intravenous recombinant tissue plasminogen activator (alteplase) as a cornerstone of treatment of acute stroke. Currently, patients are treated with intravenous…

PFO Closure for Cryptogenic Stroke
01/01/70 - Mr. Davis is a 63-year-old man who had an ischemic stroke 1 month ago and has come to you for follow-up. During his 2-day hospitalization, he underwent computed tomographic angiography of the arteries in his head and neck, and the results showed no evidence of stenosis, occlusion, or dissection.…

Study of Intraventricular Cerliponase Alfa for CLN2 Disease
01/01/70 - Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a form of Batten?s disease, is a rare, autosomal recessive, pediatric neurodegenerative disease resulting from pathogenic variants in the gene encoding lysosomal enzyme tripeptidyl peptidase 1 (TPP1). A deficiency of TPP1 results in accumulation…

Finding a Treatment for ALS ? Will Gene Editing Cut It?
01/01/70 - A key challenge in human medical genetics is developing the ability to suppress the expression of mutant genes that cause diseases that are transmitted as dominant traits. This is particularly true for the neurodegenerative disorders; many such disorders have dominantly inherited genetic forms and…

Stream of Consciousness
01/01/70 - In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors? commentary follows. A 65-year-old man presented to an emergency room in…

Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
01/01/70 - Gout is a chronic illness characterized by hyperuricemia, arthropathy, tophus development, and urolithiasis and is associated with an increased risk of cardiovascular and chronic kidney disease. The risk of cardiovascular events, including death, is substantially higher in people with gout than in…

01/01/70 - This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author?s clinical recommendations. A 55-year-old man reports…

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