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The New England Journal of Medicine: Search Results in Genetics The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. A Double-Edged Sword against Type 1 Diabetes 01/01/70 - Type 1 diabetes is an autoimmune disease leading to the destruction of insulin-producing pancreatic beta cells and subsequent hyperglycemia. Lifelong insulin treatment and long-term complications take a heavy toll on lives and bank accounts. The current epidemic in the Western world (with an… Cutting the Gordian Helix ? Regulating Genomic Testing in the Era of Precision Medicine 01/01/70 - In his 2015 State of the Union address, President Barack Obama announced a new Precision Medicine Initiative (PMI), a national investment in research on approaches to disease treatment and prevention that take into account individual variability in each person's genes, environment, and lifestyle.… Effect of Mutation Order on Myeloproliferative Neoplasms 01/01/70 - Cancers evolve as a consequence of the stepwise accumulation of somatic lesions, with competition between subclones and sequential subclonal evolution. Darwinian selection of variant subclones results in acquisition of biologic attributes required for tumor formation. Genetic interaction is central… Cancer Evolution Constrained by Mutation Order 01/01/70 - In Wonderful Life: The Burgess Shale and the Nature of History, Gould pondered the existence of species, focusing on biologic diversity in the Cambrian period more than 500 million years ago that led to the major body plans known today. He argued that the subsequent chapters of the evolutionary… Sweet's Syndrome in Patients with MDS and MEFV Mutations 01/01/70 - To the Editor: We report the finding of MEFV mutations in two Japanese patients with the myelodysplastic syndrome (MDS) and skin lesions that are consistent with Sweet's syndrome (acute febrile neutrophilic dermatosis). Both patients had heterozygous mutations in MEFV, which are known to cause… A CALR Mutation Preceding BCR-ABL1 in an Atypical Myeloproliferative Neoplasm 01/01/70 - To the Editor: Myeloproliferative neoplasms are classified into two main types according to the presence or absence of the Philadelphia chromosome with translocation t(9;22) (BCR-ABL1). Mutations in signaling genes are considered to be mutually exclusive,? although the coexistence of Janus kinase… New Approaches to Treating B-Cell Cancers Induced by Epstein?Barr Virus 01/01/70 - Epstein?Barr virus (EBV) is associated with a variety of lymphoid cancers, including Burkitt's lymphoma and Hodgkin's lymphoma. In some patients who receive immunosuppressive treatment after solid-organ or hematopoietic-cell transplantation, EBV is also associated with post-transplantation… GINA, Genetic Discrimination, and Genomic Medicine 01/01/70 - In 2008, after 13 years of advocacy by the genetics community and U.S. lawmakers, the Genetic Information Nondiscrimination Act (GINA) was signed into law. GINA is the first U.S. federal antidiscrimination statute crafted to address an area where there was no well-documented history of widespread… Mitochondrial Donation ? How Many Women Could Benefit? 01/01/70 - To the Editor: Inherited mutations in mitochondrial DNA (mtDNA) are an important cause of genetic diseases for which there is no effective treatment. New techniques that are based on in vitro fertilization (IVF), including pronuclear and metaphase II spindle transfer,, have the potential to prevent… PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma 01/01/70 - The programmed death 1 (PD-1) pathway serves as a checkpoint to limit T-cell?mediated immune responses. Both PD-1 ligands, PD-L1 and PD-L2, engage the PD-1 receptor and induce PD-1 signaling and associated T-cell "exhaustion," a reversible inhibition of T-cell activation and proliferation. By… |
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